Antioxidants Inc.

An apple slice turns brown. Fish becomes rancid. A cut on your skin is raw and inflamed. All of these result from a natural process called oxidation. It happens to all cells in nature, including the ones in your body.

To help your body protect itself from the rigors of oxidation, Mother Nature provides thousands of different antioxidants in various amounts in fruits, vegetables, whole grains, nuts, and legumes. When your body needs to put up its best defense, especially true in today’s environment, antioxidants are crucial to your health.

How Antioxidants Help Prevent Oxidation

As oxygen interacts with cells of any type – an apple slice or, in your body, the cells lining your lungs or in a cut on your skin — oxidation occurs. This produces some type of change in those cells. They may die, such as with rotting fruit. In the case of cut skin, dead cells are replaced in time by fresh, new cells, resulting in a healed cut.

This birth and death of cells in the body goes on continuously, 24 hours a day. It is a process that is necessary to keep the body healthy. “Oxidation is a very natural process that happens during normal cellular functions,” researcher Jeffrey Blumberg, PhD, professor of nutrition at Tufts University in Boston, tells WebMD.

Yet there is a downside. “While the body metabolizes oxygen very efficiently, 1% or 2% of cells will get damaged in the process and turn into free radicals,” he says.

“Free radicals” is a term often used to describe damaged cells that can be problematic. They are “free” because they are missing a critical molecule, which sends them on a rampage to pair with another molecule. “These molecules will rob any molecule to quench that need,” Blumberg says.

The Danger of Free Radicals

When free radicals are on the attack, they don’t just kill cells to acquire their missing molecule. “If free radicals simply killed a cell, it wouldn’t be so bad… the body could just regenerate another one,” he says. “The problem is, free radicals often injure the cell, damaging the DNA, which creates the seed for disease.”

When a cell’s DNA changes, the cell becomes mutated. It grows abnormally and reproduces abnormally — and quickly.

Normal cell functions produce a small percentage of free radicals, much like a car engine that emits fumes. But those free radicals are generally not a big problem. They are kept under control by antioxidants that the body produces naturally, Blumberg explains.

External toxins, especially cigarette smoke and air pollution, are “free radical generators,” he says. “Cigarette smoke is a huge source of free radicals.” In fact, our food and water also harbor free radicals in the form of pesticides and other toxins. Drinking excessive amounts of alcohol also triggers substantial free radical production.

Free radicals trigger a damaging chain reaction, and that’s the crux of the problem. “Free radicals are dangerous because they don’t just damage one molecule,” Blumberg explains. “One free radical can set off a whole chain reaction. When a free radical oxidizes a fatty acid, it changes that fatty acid into a free radical, which then damages another fatty acid. It’s a very rapid chain reaction.”

These external attacks can overwhelm the body’s natural free-radical defense system. In time, and with repeated free radical attacks that the body cannot stop, that damage can lead to a host of chronic diseases, including cancer, heart disease, Alzheimer’s disease, and Parkinson’s disease.

Oxidative damage in skin cells is caused by cumulative sunlight. But if free radicals are in an internal organ – for example, if asbestos is in your lungs — it stimulates free radical reactions in lung tissue. “Cigarette smoke has active free radical generators,” says Blumberg. That’s why stopping smoking is the biggest step anyone can take to preserving their health.

Getting Antioxidants in Your Diet

In the 21st century, people need to get more antioxidants in their diet to offset all these assaults, he says. “These toxins are ubiquitous in the environment. If you live in a city, you breathe the air. The oxidative burden [on the body] is much, much, much higher than it was 200 years ago. It’s a fact of modern life, so we have to take that into consideration.”

When you follow the USDA’s advice to eat multiple servings of fruits and vegetables, you’re compensating for the effects of environmental toxins. Your body simply doesn’t produce enough antioxidants to do all that, says Blumberg.

What exactly do they do? Antioxidants work to stop this damaging, disease-causing chain reaction that free radicals have started. Each type of antioxidant works either to prevent the chain reaction or stop it after it’s started, Blumberg explains.

Types of Antioxidants

“For example, the role of vitamin C is to stop the chain reaction before it starts,” he says. “It captures the free radical and neutralizes it. Vitamin E is a chain-breaking antioxidant. Wherever it is sitting in a membrane, it breaks the chain reaction.”

Flavonoids are the biggest class of antioxidants. Researchers have identified some 5,000 flavonoids in various foods, Blumberg tells WebMD.

Polyphenols are a smaller class of antioxidants, which scientists often refer to as “phenols.” (Terms like phytonutrient and phytochemical are more generic terms that researchers sometimes use to describe nutrients and chemicals in plants.)

“We have clear science about antioxidants, that our bodies need a Natural Antioxidant Defense Network, for lack of a better term,” Blumberg says. “Just like a country needs a military system, the human body needs defense workers at all levels — lieutenants, corporals, generals, staff sergeants – in the form of antioxidants.”

Getting the Right Mix of Antioxidants

The body needs a mix of vitamins and minerals, such as vitamins A, C, E, and beta-carotene, to neutralize this free radical assault.

“We can’t rely on a few blockbuster foods to do the job,” says Blumberg. “You can’t eat nine servings of broccoli a day and expect it to do it all. We need to eat many different foods. Each type works in different tissues of the body, in different parts of cells. Some are good at quenching some free radicals, some are better at quenching others. When you have appropriate amounts of different antioxidants, you’re doing what you can to protect yourself.”

Multivitamins and vitamin supplements can provide the body with an antioxidant boost. Yet getting too much of some supplements, like vitamin E, can be harmful. Fruits, vegetables, whole grains, legumes, and nuts contain complex mixes of antioxidants, and therein lies the benefit of eating a variety of healthy foods, says Blumberg.

Researchers continue delving into the mysteries of fruits and vegetables, identifying the complex antioxidants they contain. Quercetin, luteolin, hesperetin, catetchin, even (-)-epigallocetechin are some of the stars they have found — the blockbuster flavonoids in our foods.

“Sure, you can live your whole life without getting epicatechin 3-gallate, a flavonoid found in huge quantities in green tea,” says Blumberg. “But if having it in your diet promotes better health, why not try it?”

Vitamin E is a fat-soluble vitamin that exists in eight different forms. Each form has its own biological activity, which is the measure of potency or functional use in the body. Alpha-tocopherol (?-tocopherol) is the name of the most active form of vitamin E in humans. It is also a powerful biological antioxidant. Vitamin E in supplements is usually sold as alpha-tocopheryl acetate, a form of alpha-tocopherol that protects its ability to function as an antioxidant. The synthetic form is labeled “D, L” while the natural form is labeled “D”. The synthetic form is only half as active as the natural form

It has been claimed that ?-tocopherol is the most important lipid-soluble antioxidant, and that it protects cell membranes from oxidation by reacting with lipid radicals produced in the lipid peroxidation chain reaction. This would remove the free radical intermediates and prevent the oxidation reaction from continuing. The oxidised ?-tocopheroxyl radicals produced in this process may be recycled back to the active reduced form through reduction by other antioxidants, such as ascorbate, retinol or ubiquinol. However, the importance of the antioxidant properties of this molecule at the concentrations present in the body is not clear and it is possible that the reason why vitamin E is required in the diet is unrelated to its ability to act as an antioxidant. Other forms of vitamin E have their own unique properties. For example, ?-tocopherol (also written as gamma-tocopherol) is a nucleophile that may react with electrophilic mutagens; and the tocotrienols having specialized roles in protecting neuronsfrom damage, cancer prevention and cholesterol reduction by inhibiting the activity of HMG-CoA reductase[16-1];?-tocotrienol blocks processing of sterol regulatory element?binding proteins (SREBPs)[16-1].However, the roles and importance of all of the various forms of vitamin E are presently unclear,^[10][11] and it has even been suggested that the most important function of vitamin E is as a signaling molecule, and that it has no significant role in antioxidant metabolism.

Most studies about vitamin E have supplemented using only the synthetic alpha-tocopherol, but doing so leads to reduced serum gamma- and delta-tocopherol concentrations. Moreover, a 2007 clinical study involving synthetic alpha-tocopherol concluded that supplementation did not reduce the risk of major cardiovascular events in middle aged and older men. For more info, read article tocopherol.

Particularly high levels of vitamin E can be found in the following foods:

• Avocado
• Nuts, such as almonds or hazelnuts
• Red Palm Oil
• Seeds
• Spinach and other green leafy vegetables
• Vegetable oils – Canola, corn, sunflower, soybean, cottonseed, olive oil
• Wheat germ
• Wholegrain foods
• Milk
• Asparagus

What are free radicals? Why are they damaging to the human body? And how does vitamin E and the other antioxidant nutrients help protect the body against free radical damage? We?ll attempt to answer these questions and help you understand why eating 5-8 servings per day of anti-oxidant rich fruits and vegetables can benefit your health. But first, a little background?

Background: A Brief Look at Chemical Bonding

To understand the way that free radicals and antioxidants interact, you must first understand a bit about cells and molecules.  So here’s a (very) brief refresher course in Physiology/Chemistry 101:  The human body is composed of many different types of cells. Cells are composed of many different types of molecules. Molecules consist of one or more atoms of one or more elements joined by chemical bonds.

As you probably remember from your old high school days, atoms consist of a nucleus, neutrons, protons and electrons. The number of protons (positively charged particles) in the atom?s nucleus determines the number of electrons (negatively charged particles) surrounding the atom. Electrons are involved in chemical reactions and are the substance that bonds atoms together to form molecules. Electrons surround, or “orbit” an atom in one or more shells. The innermost shell is full when it has two electrons. When the first shell is full, electrons begin to fill the second shell. When the second shell has eight electrons, it is full, and so on. 

The most important structural feature of an atom for determining its chemical behavior is the number of electrons in its outer shell. A substance that has a full outer shell tends not to enter in chemical reactions (an inert substance). Because atoms seek to reach a state of maximum stability, an atom will try to fill it?s outer shell by:

• Gaining or losing electrons to either fill or empty its outer shell
• Sharing its electrons by bonding together with other atoms in order to complete its outer shell

Atoms often complete their outer shells by sharing electrons with other atoms. By sharing electrons, the atoms are bound together and satisfy the conditions of maximum stability for the molecule.

How Free Radicals are Formed

Normally, bonds don?t split in a way that leaves a molecule with an odd, unpaired electron. But when weak bonds split, free radicals are formed. Free radicals are very unstable and react quickly with other compounds, trying to capture the needed electron to gain stability. Generally, free radicals attack the nearest stable molecule, “stealing” its electron. When the “attacked” molecule loses its electron, it becomes a free radical itself, beginning a chain reaction. Once the process is started, it can cascade, finally resulting in the disruption of a living cell.

Some free radicals arise normally during metabolism. Sometimes the body?s immune system?s cells purposefully create them to neutralize viruses and bacteria. However, environmental factors such as pollution, radiation, cigarette smoke and herbicides can also spawn free radicals.

Normally, the body can handle free radicals, but if antioxidants are unavailable, or if the free-radical production becomes excessive, damage can occur. Of particular importance is that free radical damage accumulates with age.

How Antioxidants May Prevent Against Free Radical Damage

The vitamins C and E, are thought to protect the body against the destructive effects of free radicals. Antioxidants neutralize free radicals by donating one of their own electrons, ending the electron-”stealing” reaction. The antioxidant nutrients themselves don?t become free radicals by donating an electron because they are stable in either form They act as scavengers, helping to prevent cell and tissue damage that could lead to cellular damage and disease.

Vitamin E ? The most abundant fat-soluble antioxidant in the body. One of the most efficient chain-breaking antioxidants available. Primary defender against oxidation. Primary defender against lipid peroxidation (creation of unstable molecules containing more oxygen than is usual).

Vitamin C ? The most abundant water-soluble antioxidant in the body. Acts primarily in cellular fluid. Of particular note in combating free-radical formation caused by pollution and cigarette smoke. Also helps return vitamin E to its active form.

The Antioxidants and Disease Prevention

• Heart Disease ? Vitamin E may protect against cardiovascular disease by defending against LDL oxidation and artery-clogging plaque formation.
• Cancer ? Many studies have correlated high vitamin C intakes with low rates of cancer, particularly cancers of the mouth, larynx and esophagus.

The Lesson:  Eat Your Fruits and Vegetables!

The antioxidants are believed to help protect the body from free-radical damage. But before you go out and stock your pantry with mega-doses of these vitamins, be warned: more is not always better. The long-term effect of large doses of these nutrients has not been proven. Other chemicals and substances found in natural sources of antioxidants may also be responsible for the beneficial effects. So for now, the best way to ensure adequate intake of the antioxidant nutrients is through a balanced diet consisting of 5-8 servings of fruits and vegetables per day.

What is AntiOxidant?

An antioxidant is a molecule capable of slowing or preventing the oxidation of other molecules. Oxidation is a chemical reaction that transfers electrons from a substance to an oxidizing agent. Oxidation reactions can produce free radicals, which start chain reactions that damage cells. Antioxidants terminate these chain reactions by removing free radical intermediates, and inhibit other oxidation reactions by being oxidized themselves. As a result, antioxidants are often reducing agents such as thiols or polyphenols.

Although oxidation reactions are crucial for life, they can also be damaging; hence, plants and animals maintain complex systems of multiple types of antioxidants, such as glutathione, vitamin C, and vitamin E as well asenzymes such as catalase, superoxide dismutase and various peroxidases. Low levels of antioxidants, or inhibition of the antioxidant enzymes, causesoxidative stress and may damage or kill cells.

As oxidative stress might be an important part of many human diseases, the use of antioxidants in pharmacology is intensively studied, particularly as treatments for stroke and neurodegenerative diseases. However, it is unknown whether oxidative stress is the cause or the consequence of disease. Antioxidants are also widely used as ingredients in dietary supplements in the hope of maintaining health and preventing diseases such as cancer and coronary heart disease. Although initial studies suggested that antioxidant supplements might promote health, later large clinical trials did not detect any benefit and suggested instead that excess supplementation may be harmful. In addition to these uses of natural antioxidants in medicine, these compounds have many industrial uses, such as preservatives in food and cosmetics and preventing the degradation of rubber and gasoline.

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